نتایج جستجو برای: Multiple Myeloma prognosis
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The crow-fukas, Takatsuki or POEMS syndrome (The acronym of Polyneuropathy, Organomegaly, endocrinopathy, M component and skin changes), a rare, multisystem disorder associated with osteosclerotic myeloma, is characterize by the combination of plasma cell discrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal(M) protein, skin changes, as well as various other sign, such...
Multiple myeloma is a monoclonal malignant proliferation of plasma cells that causes osteolytic lesions in the vertebrae, ribs, pelvic bone, skull and jaw. We report a case of a 66 year-old-woman with pain and right facial swelling. Radiographic examination showed a well-defined radiolucent lesion in left posterior mandible. An incisional biopsy was performed and histopathological examination r...
Background & Aims: Acute phase proteins are synthesized mainly by the liver and macrophages in an inflammatory conditions as a result of some trauma and malignancies. Increased levels of these proteins have been reported in many cancer tumors and multiple myeloma as an important indicator of prognosis of malignancies. Because of importance of this issue, we investigate the serum level ...
The acronym CRAB summarizes the most typical clinical manifestations of multiple myeloma, these being hypercalcemia, renal failure, anemia, and bone disease. CRAB can be used to distinguish between active, symptomatic multiple myeloma and monoclonal gammopathy of undermined significance or smoldering myeloma. The distinction is relevant not only for classification and diagnosis but also for the...
a 54 year old man with history of cardiomyopathy and chronic fibrillation first presented with bloody diarrhea. then during the assessment of his abnormal lab. data revealed cast nephropathy in renal biopsy, gamma peak in protein electrophoresis and fine lytic lesions in skull graphy. his bone marrow aspiration showed multiple myeloma and blood smear revealed plasma cell leukemia. our patient w...
introduction plasma cell dyscrasias are characterized by a monoclonal neoplastic proliferation of plasma cells. solitary bone plasmacytoma (sbp) is a local form of the disease with the vertebrae and long bones being the most frequently encountered sites. its prevalence in the maxillofacial area is extremely rare. case presentation a 70-year-old caucasian male patient was referred for the extrac...
Introduction: Multiple myeloma is a heterogeneous disease with different survival times among patients. Accurate prediction of prognosis in multiple myeloma is essential, as patients with a shorter survival time may require early bone marrow transplantation (BMT) and more advanced chemotherapy as a part of their first-line treatment. In the present study, a parameter, depicted by ga...
Multiple Myeloma is a neoplasm of B cell lineage characterized by excessive proliferation of abnormal plasma cells. It is characterized by a clinical pentad of 1) anemia, 2) a monoclonal protein in the serum or the urine or both, 3) bone leisons and or bone pain, 4) hypercalcemia >11.5g/dl and 5) renal insufficiency. Non secretory multiple myeloma is a rare variant of the classic form of multi...
Extramedullary plasmacytoma occurs in 18% of patients with multiple myeloma. Laryngeal involvement in multiple myeloma is rare, and only a few cases have been reported. We present a case of a 44-year-old women with multiple myeloma who presented with stridor due to a mass involving the larynx which was initially proven to be plasmacytoma on biopsy. She had evidence of multiple myeloma of IgA la...
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